Aug 302010
 

On the eve of the big Alzheimer’s Breakthrough bike ride, I was sequestered with my fellow riders, John Cirrito and Jess Resvito from Washington University, and Ben Timson, from Missouri State University, at the Comfort Inn in Sedalia. Since I hang out at the University of Missouri (in Columbia), we had most of the state covered. I think all of us were excited and a bit nervous, at least I was. Adding to my anxiety [...]

Aug 302010
 

Thursday morning, August 26th, 2010, started off in a wonderful way. Unlike the last 8 weeks in St. Louis and the rest of Missouri where the high temperatures were averaging 95-100 with similar humidity, it was an absolutely perfect day for riding. After a nice breakfast with our wonderful crew of Evan, Melanie, and Glen, we started with a signing event in the state capital of Missouri, Jefferson City. It was well attended by staff [...]

Aug 302010
 

My Breakthrough ride started in Saint Louis Airport where I rented the car that would take me and my bike to Kansas City to Pick up Jeff Burns and then take the two of us to Wichita, KS. Driving to Kansas City, I went through two big storm systems and as I pulled in, the rain started pouring there also. I was hoping this would not be a sign of things to come. After picking [...]

Aug 302010
 

This past weekend, I began my segment of the Alzheimer’s Breakthrough Ride, a one-day journey from St. Louis, Miss. to Springfield, Ill. As the president of U.S. financial products at Genworth Financial, I can say that we are proud to be a Champion of the Alzheimer’s Early Detection Alliance, helping to increase awareness of the impact of Alzheimer’s disease. As an avid cyclist, the Alzheimer’s Breakthrough Ride was a wonderful opportunity to combine my interests: [...]

Aug 262010
 
Alzheimer’s Breakthrough Ride Journal: Segment 10, Day 1

Oklahoma City to Tonkawa 5:45 AM on August 18th marked the beginning of my long anticipated ride from Oklahoma City to Wichita, Kansas and also the midpoint of the Breakthrough Ride. I had the wonderful opportunity to attend the signing event in Oklahoma City the previous day, where I was further inspired for my ride by the volunteers and the many people willing to sign the petition and recognize the importance of Alzheimer’s disease at [...]

Aug 262010
 

Dear Readers, The “hippocampal theta rhythm” is a specific type of electrical activity that can be observed in the hippocampus and other brain structures in numerous species of mammals including rodents, rabbits, dogs, cats, bats and marsupials. In the oldest EEG literature dating back to the 1920s, Greek letters such as alpha, beta, theta and gamma were used to classify EEG waves falling into specific frequency ranges, with “theta” generally meaning a range of about [...]

Aug 232010
 
Alzheimer’s Breakthrough Ride Journal: Segment 9

Joachim Herz, M.D., is a professor at the Graduate School of Biomedical Sciences at Southwestern Medical School in Dallas. Dr. Herz’s research has identified several fundamental molecular mechanisms that are common to both Alzheimer’s disease and atherosclerosis. This summer, he is participating in the Alzheimer’s Breakthrough Ride to raise awareness and make Alzheimer’s disease a national priority. Dr. Herz’s segment of the ride began on August 16 in Dallas and ended on August 18 in [...]

Aug 232010
 
Dementia in the Asian Community: Is it Due to Alzheimer’s Disease or Vascular Disease?

Dear Readers, Have you heard the saying “Things come in three’s?” Well, that was the case this month when over a three week period, I was asked the following question three times, at three separate Asian community health events “Which type of dementia is more common in Asians — Alzheimer’s disease or vascular dementia?” A similar question was posed in a recently published study that sought to examine the trends in prevalence (existing cases) of [...]

Aug 182010
 

Dallas to Whitesboro, TX As my plane was about to land in Dallas on Sunday, the pilot announced that the temperature was 102. On Sunday evening the meteorologist on a local TV station described Monday as a cooler day, his forecast: temperature 101, heat index 110. Monday morning at 5:45, I met Joachim Herz, the researcher-rider on this segment, and Melanie Katz, the “ride mother”, in the lobby of the Courtyard on I-35. After a [...]

Aug 182010
 
What Does the Cessation of the Lilly Semagacestat Study Mean?

Readers, Eli Lilly and Company announced yesterday that it is halting development of semagacestat, a gamma-secretase inhibitor being studied as a potential treatment for Alzheimer’s disease. The decision was made after preliminary results from two separate phase 3 studies showed that the drug did not slow disease progression and worsened cognition and the ability to perform activities of daily living. In the 2 trials, called IDENTITY (Interrupting Alzheimer’s Dementia by EvaluatiNg Treatment of AmyloId PaThologY) [...]

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