Sep 302010
 

As we move forward in our understanding of the underlying mechanisms of Alzheimer’s disease, insights are constantly emerging from many different fronts. The disease is quite complex, and facts discerned by each new discovery must be assembled into an ever evolving theory. Sometimes, results that initially seem to be at odds with previous findings turn out to be integral to a clearer understanding of the disease. In the field of Alzheimer research, there have been […]

Sep 222010
 
Brain Atrophy and B Vitamins

Brain atrophy involves the loss of neurons. Some degree of atrophy and subsequent brain shrinkage is common with old age, even in people who are cognitively healthy. However, this atrophy is accelerated in people with mild cognitive impairment and even faster in those who ultimately progress from mild cognitive impairment to Alzheimer’s disease. Many factors have been implicated in affecting the rate of brain atrophy, one of which is high levels of an amino acid […]

Sep 212010
 

Today, World Alzheimer’s Day 2010, we have seen new levels of attention around the reality of Alzheimer’s disease, including the millions affected in the United States and across the globe. More than 40 research riders in the Alzheimer’s Breakthrough RideSM arrived in Washington, D.C. to deliver the signatures of over 100,000 Americans who want Congress to make Alzheimer’s a national priority. Alzheimer’s Disease International released the new World Alzheimer Report 2010, highlighting the growing costs […]

Sep 202010
 
Alzheimer’s Breakthrough Ride Journal: Indianapolis to Ann Arbor

In light of what those who rode before us have endured, I wish I had a tale of woe to tell, but alas, this particular segment of the Alzheimer’s Breakthrough Ride was nothing shy of epic riding. We had trained for all conditions…except perfection. By the mid-afternoons, it was mostly sunny and in the low 80s. The few clouds that were present had that distinct late summer softness to their contours. If it can be […]

Sep 192010
 

First of all, I am not an Alzheimer’s Researcher. I am what was often referred to as an “other,” meaning I have a personal connection to Alzheimer’s disease. My wife is a genetics researcher and a colleague of Dr. Bruce Lamb. Bruce sent a fundraising email to my wife, she forwarded it to me thinking I would “sign the petition and donate $50.” Instead I emailed Bruce, explained my story and asked to join the […]

Sep 172010
 
Alzheimer’s Breakthrough Ride Journal: Ann Arbor to Cleveland Day 2

The second day of the ride from Ann Arbor to Cleveland started similar to the first. It was a crisp, cool (52 degrees) morning as we headed out of Perrysburg towards Sandusky at 7 AM (a total of a little more than 60 miles). Although a bit warmer than the first morning, Charlie and I still had on our tights, gloves and windbreakers for the first few hours of the morning. There was also a […]

Sep 152010
 
The Connection Between Amyloid, Tau and FYN

Readers, Amyloid plaques and neurofibrillary tangles (NFTs) are the two classic hallmarks of Alzheimer’s disease (AD), but the connection between their two respective proteins—beta-amyloid and tau—has remained mysterious. Now, a paper published on July 21 in the prestigious journal Cell details a molecular mechanism that links tau to beta-amyloid toxicity at the synapse. The groundbreaking new study was led by Professor Jürgen Götz and Dr Lars Ittner, based at the University of Sydney. Back in […]

Sep 102010
 

I started my adventure at the signing event in Ann Arbor on Thursday afternoon where I was deeply moved by the story told by a young lady about her life with a 31 year old husband who had early onset Alzheimer’s disease. We started our trip early the next morning on a sunny day. Thankfully it was cool, which prompted me to wear several layers of clothing. This served me well shortly after breakfast when […]

Sep 102010
 
Alzheimer’s Breakthrough Ride Journal: Madison to Chicago and Points Beyond

My journey on the Alzheimer’s Breakthrough Ride would consist of three days of riding. Two days to complete the Madison-Chicago segment and an additional day to ride the first leg of the Chicago to Indy segment. Each day brought something new: meeting great new friends, inspiration in the fight against Alzheimer’s, and great riding through America’s heartland. I finished up our lab work on Tuesday and headed to Madison, where the weather looked rather daunting […]

Sep 092010
 
Alzheimer’s Breakthrough Ride Journal: Madison to Chicago Part 2

On Tuesday morning I met my fellow riders (Eric — who I believe is still on the road) and Michael. My friend and colleague Barb was there also, and Mel, Glenn, and Evan — the most fabulous, helpful road crew a bicyclist could ever hope for!! (Thanks you guys!) The organization of this event and the people I got to meet made this a fantastic experience. Day 1 was spent riding through country roads of […]

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